High school sweethearts Tsukasa and Tsukushi are finally getting married. Tsukasa gives his fiancee a precious family heirloom; only to see a robber disappear with it. Tsukasa and his F4 friends reunite for the globetrotting search.

Makino Tsukushi is the only poor student at Eitoku Gakuen, a school for the ridiculously rich and privileged. Eitoku Gakuen is ruled by the Flower 4, or otherwise known as the F4, a group of four boys who come from extremely powerful families: Domyoji Tsukasa, the leader and heir of the Domyoji World Finance Group; Hanazawa Rui, the introverted son of a large company; Nishikado Sojiro, a player who is the heir of a tea ceremony school; and Mimasaka Akira, a madam killer with ties to the underground. If a student gets on the F4's bad side, he/she gets a red notice and is bullied and driven out of school.
Makino hopes to pass her days quietly - without drawing any attention to herself - but one day, she stands up to Domyoji in defense of her friend. The next day, Makino receives the dreaded red notice. Even though she is harassed, Makino decides to keep going to school and declares war right back on the F4, because she is a "tough weed." Her resolve gets the attention of her crush, Hanazawa Rui, and oddly enough, rouses romantic feelings in her worst enemy, Domyoji Tsukasa.

This second season of Hana Yori Dango picks up right after Domyoji leaves for New York. After confessing to Domyoji, Makino has not spoken to him for a year. Rui and the other members of F4 try and help Makino meet Domyoji again by going to New York for the christmas holidays. Though F4 and Makino meet Domyoji again, he has become a completely different person, and so they leave for Japan. Some time later, Domyoji's mother annouces that they will be returning to Japan. There, they hold a giant super-rich and classy birthday party for Domyoji and announce something very important. Domyoji, like in the first season, is engaged to a rich girl and heir, Shigeru. The only difference is that they are to be wed soon. What will Makino do?
On the side, Rui begins to fall in love with Makino. Will this become a love square?

The special took place half a year after the series' end. With Osaka Gakuen getting ready for an upcoming Valentine's Day event, Sano and Nakatsu reflect on the final week of their last summer vacation, which falls into the timeline of the original series between episodes 7 and 8. The special also includes a graduation scene and addresses the relationship between Mizuki and Sano.

The management company of the idol group A.N.JELL insisted on adding a new singer to the group as the lead vocal, Tae Kyung's voice was hurting. However,the new member, Mi Nam, had to go to the States to repair a botched eye job just before signing the contract. His agent came up with the idea of having his twin sister, Mi Nyu,to stand in for him and pretend that she was her brother. The two of them grew up in an orphanage and Mi Nyu, who was all set to become a nun, agreed to this charade as she didn't want to spoil her brother's chance of fame which would make it easier to look for their mother.

Choi Han Gyul is the grandson of chairwoman Bang of Dong-in Foods, a company that has a thriving coffee business. He has never had a job and does not care for responsibility. Han Gyul is hung up on his first love, Han Yoo Joo, who only sees him as a friend.

Go Eun Chan is a 24-year-old tomboy who is often mistaken for a guy. Her father died when she was 16 years old and since then she has taken over as the breadwinner in her family.

When Han Gyul and Eun Chan meet, he, not knowing that she is a girl, decides to hire her to pretend to be his gay lover so that he can escape the blind dates arranged by his grandmother. After getting an ultimatum from his grandmother, Han Gyul takes over a rundown old coffee shop, later renamed "Coffee Prince," to prove that he's capable, to both his grandmother and Yoo Joo. In order to attract female customers, he only hires good-looking male employees. Eun Chan, desperate for money, continues to hide her gender to get a job at the Coffee Prince.

When a total eclipse of the sun takes place, Go Ha Jin is transported back in time to the start of the Goryeo Dynasty of Korea during King Taejo's rule. She wakes up in the body of the 16-year-old Hae Soo and finds herself living in the house of the 8th Prince Wang Wook, who is married to Hae Soo's cousin. She soon befriends several of the princes and meets the ostracized 4th Prince, Wang So. Although knowing she should not get involved in palace intrigues over the succession to the throne, she inadvertently becomes a pawn in the struggle, as several of the Princes fall in love with her.

Geum Jan Di comes from a poor family who owns a dry-cleaning shop. One day, she visits Shinhwa High School, a prestigious school for the wealthy, and saves a student trying to commit suicide because of bullying. For her heroic act, Jan Di receives a swimming scholarship and starts attending the school.

In Shinhwa High, she meets the notorious F4, the most popular and powerful group of boys at the school, consisting of Gu Jun Pyo; the leader of F4 and heir to the Shinhwa Group, Yoon Ji Hu; the grandson of a former president of Korea, So Yi Jung; a skilled potter who comes from a family that owns the country's biggest art museum, and Song Woo Bin; whose family runs the country's largest construction company.

Her life at school starts out miserable, as she doesn't fit in with other students because of her status, and later becomes worse when she is labeled as the new bullying target of the F4.

Feisty, bubbly, and no-nonsense, Chae Gyeong is an ordinary high school student. Until one day when she receives some unexpected news. Because of her grandfather's will, she must marry the unendurable Crown Prince Lee Shin who also happens to attend her high school. Chae Gyeong initially resists the proposal before reluctantly agreeing to marry him to help her debt-ridden family.

As she struggles to adapt herself to royal life, learning proper manners and taking on the duties of palace life while dealing with a disagreeable husband, the Crown Prince's sentimental cousin and second-in-line to the throne, Yul, steps into her life. She feels like she can rely on Yul for help and guidance but still finds it difficult not to worry about her haughty, cold-hearted husband.

To help bridge this gap, the senior members of the royal family take some special measures to get them to spend the night together.

Adopted by middle classed parents, Xiao Mai has always had a dream to be an heiress. Who knew that one day this dream would come true. Xiao Mai's biological grandfather is the head of a prestigous aristocratic family and after many years of searching, he finally finds his long lost granddaughter. As she starts her life as an heiress, everyday is filled with excitement, however, everything seems a bit different from what she had imagined them to be.

When Mugi Aihara read, in her favorite magazine, that the heirs to four of the biggest corporations in Japan were on a public quest to find their one true love, she could hardly believe what she was reading. When she realized these four gorgeous princes were searching for their destined princess via a new reality show, she dropped everything she was doing and immediately started filling out a contestant application.

A few days later, Mugi got the shock of her life when she received a text informing her that among the 700,000 applications vying for the chance to participate in "Marry the Prince", she had been selected as one of the three lucky contestants. Besides herself with joy, she happily accepted the invitation, along with two other high school students, Fumino Ono and Yu Shibayma. Together, the three girls excitedly begin filming, only to find that life as a reality show contestant isn't exactly what they'd imagined it would be.

Wealthy and entitled, Riku Nikaido, Taiga Saionji, Terunoshin Minai, and Tatsunari Date were far from the dashing princes of fairy tales. Caught up in the drama of their own lives, the four princes have more fun teasing the girls than they do wooing them as none of them really believe they'll actually find true love. But each of the participants soon learns that fate can be a funny thing and that love has a way of finding you when you least expect it.

Dogai Ryuga, the Golden Knight Garo, has regained his golden glow and destroyed the evil plots of Horror. An encounter with a mysterious knight clad in “steel” leads Ryuga to the next test. Now, the story that approaches the origin of the protector begins!