No Min-woo made his debut as the drummer (with the stage name Rose) in the rock band TRAX in 2004. He left the band in 2006, and briefly became a guitarist for The Romantist before it disbanded. In 2009 he returned to the music scene as the leader of the project group 24/7, with Lee Jang-woo and Hyun Woo. They released the single 24 Hours a Day, 7 Days a Week.
He began pursuing an acting career in 2008, and gained notice with his supporting roles in the 2010 TV series Pasta and My Girlfriend is a Nine-Tailed Fox. He landed his first leading role in the four-episode drama special Rock Rock Rock, a biopic about the life of Boohwal lead guitarist Kim Tae-won. Then for his role as a cancer patient in 2011's Midas, No lost 9.5 kilograms (21 pounds). His long-delayed drama Full House Take 2 (a loose sequel to the 2004 hit) secured air dates on Japan's TBS and Korean cable channel SBS Plus in 2012. No was cast as the male lead in the Chinese TV series Love Expiration Date, for which he will also serve as OST music director, composing and writing songs for the soundtrack.