In
Scent of a Woman, the main character decides to completely change her way of living when she discovers that she has cancer. (Note: this is not the tragi,c dramatic kind of sad drama where everything goes wrong just because a character has cancer.)
In
Yankee-kun to Megane-chan, the main characters change from good school kid to deliquent and vice versa.
In
IS - Otoko Demo Onna Demo Nai Sei, the main character who is intersex and grew up as a boy, has to attend high school like a girl. This drama is honestly one of the best dramas I've ever seen. (I'm usually just infatuated by an actor/actress or the theme of a drama but this is just superior quality that you have to acknowledge :P)
Thee very different dramas... ^^ I hope at least one fits what you're looking for :)