"In Hand" (2019) stands out not just for its intriguing plot but also for the humor and chemistry between its main characters. Dr. Himokura Tetsu, portrayed by Yō Ōizumi, brings a delightful eccentricity to the screen. His oddball behavior, paired with his genius-level intellect, creates many humorous moments, particularly in his interactions with the other characters.

The dynamic between Dr. Himokura and his two main partners, Makino (Fumino Kimura) and Takaie (Tomoya Nakamura), is where the show truly shines. The contrast between Himokura’s quirky, reclusive nature and Makino’s strict, by-the-book approach leads to plenty of witty banter and comedic tension. Meanwhile, Takaie's enthusiasm and naivety add a light-hearted element to the group, making for some genuinely funny scenes as he tries to navigate the often bizarre situations they encounter.

The chemistry between the trio is palpable, with each character bringing something unique to the table. Their interactions, filled with both camaraderie and mild exasperation, add a layer of warmth and humor to the show, making it more than just a medical mystery drama. It's this blend of comedy, strong character dynamics, and intriguing plots that make "In Hand" a highly enjoyable series, especially for those who appreciate a good laugh alongside their mysteries.