Leads with "Kryptonite"
These are dramas in which one (or both) of the leads has a fatal weakness such as a phobia, mental illness, or disability that interferes with their lives.
I am including supernatural weaknesses but only those that are chronic long-time conditions or weaknesses that consistently create conflict for the heroes.
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1. Perfect Marriage Revenge
Korean Drama - 2023, 12 episodes
ML - water phobia
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2. Please Feel at Ease Mr. Ling
Chinese Drama - 2021, 24 episodes
ML - water phobia
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3. The Beauty Inside
Korean Drama - 2018, 16 episodes
ML - face blindness
FL - one week per month she changes in a different person physically -
4. The Secret Life of My Secretary
Korean Drama - 2019, 32 episodes
ML - face blindness
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5. What's Wrong with Secretary Kim
Korean Drama - 2018, 16 episodes
ML - fear of zip ties and of physical intimacy
FL - arachnophobia -
6. Business Proposal
Korean Drama - 2022, 12 episodes
ML - rain phobia
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7. Lost Romance
Taiwanese Drama - 2020, 20 episodes
ML - fear of darkness
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8. The Brightest Star in the Sky
Chinese Drama - 2019, 44 episodes
ML - fear of fire
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9. Ugly Beauty
Chinese Drama - 2021, 24 episodes
ML - fear of fire
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10. Sm:)e
Chinese Drama - 2018, 24 episodes
ML - skin contact phobia
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11. I'm Not a Robot
Korean Drama - 2017, 32 episodes
ML - "people allergy" i.e. agoraphobia
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12. About Is Love
Chinese Drama - 2018, 30 episodes
ML - OCD, fear of women
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13. My Holo Love
Korean Drama - 2020, 12 episodes
FL - face blindness
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14. Love with Flaws
Korean Drama - 2019, 32 episodes
ML - his IBS acts up whenever he's reminded of childhood trauma; mild mysophobia; also, heavily implied that he has an eating disorder
FL's brother also has a fear of the dark
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15. A Good Day to Be a Dog
Korean Drama - 2023, 14 episodes
FL - turns into a dog if she kisses someone
ML - fear of dogs (ironically) -
16. Dusk Love
Chinese Drama - 2024, 24 episodes
FL - fear of the dark, thunderstorms
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17. Timeless Love
Chinese Drama - 2021, 24 episodes
ML - PTSD, claustrophobia
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18. It's Okay, That's Love
Korean Drama - 2014, 16 episodes
ML - schizophrenia, OCD
FL - fear of intimacy
SML - Tourette's syndrome -
19. Story of Kunning Palace
Chinese Drama - 2023, 38 episodes
ML - schizophrenia
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20. It's Okay to Not Be Okay
Korean Drama - 2020, 16 episodes
FL - psychopathy
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21. Just Between Lovers
Korean Drama - 2017, 16 episodes
FL - claustrophobia
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22. Clean with Passion for Now
Korean Drama - 2018, 16 episodes
ML - OCD, mysophobia
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23. King the Land
Korean Drama - 2023, 16 episodes
ML - strong aversion to smiles
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24. Mad for Each Other
Korean Drama - 2021, 13 episodes
FL - anxiety/paranoid disorder
ML - anger management disorder -
25. I Love My President Though He's A Psycho
Chinese Drama - 2017, 10 episodes
ML - paranoid disorder
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26. 100 Days My Prince
Korean Drama - 2018, 16 episodes
SML - face blindness
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27. Well Dominated Love
Chinese Drama - 2020, 24 episodes
ML - OCD
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28. Yamato Nadeshiko Shichi Henge
Japanese Drama - 2010, 10 episodes
FL - social anxiety
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29. Healer
Korean Drama - 2014, 20 episodes
FL - panic/anxiety disorder due to PTSD, triggered around violent situations
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30. Love Is Sweet
Chinese Drama - 2020, 36 episodes
FL - "tear allergy" as in, she gets sick whenever she cries
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31. Kuragehime
Japanese Drama - 2018, 10 episodes
FL - social anxiety
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32. Witch's Castle
Korean Drama - 2015, 122 episodes
FL - fear of fire
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33. Flower Boy Next Door
Korean Drama - 2013, 16 episodes
FL - agoraphobia, social anxiety
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34. Secret Garden
Korean Drama - 2010, 20 episodes
claustrophobia
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35. The Tale of Nokdu
Korean Drama - 2019, 32 episodes
FL - fear of the dark
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36. Assistant of Superstar
Chinese Drama - 2022, 24 episodes
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37. Love in Time
Chinese Drama - 2020, 24 episodes
ML - fear of the dark
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38. The Perfect Match
Taiwanese Drama - 2017, 22 episodes
fear of the dark
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39. Sweet Sweet
Chinese Drama - 2021, 22 episodes
ML - aphasia (language disability)
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40. Lovers of the Red Sky
Korean Drama - 2021, 16 episodes
ML - blindness (originally the FL was blind)
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41. That Winter, the Wind Blows
Korean Drama - 2013, 16 episodes
FL - blindness
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42. Flower of Evil
Korean Drama - 2020, 16 episodes
ML - schizophrenia
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43. Koi Desu: Yankee-kun to Hakujou Garu
Japanese Drama - 2021, 10 episodes
FL - blindness
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44. Angel's Last Mission: Love
Korean Drama - 2019, 32 episodes
FL - blindness
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45. Forever Love
Chinese Drama - 2020, 28 episodes
FL - blindness
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46. Lucky Romance
Korean Drama - 2016, 16 episodes
FL - cursed with bad luck
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47. Love Me in Three Days
Chinese Drama - 2022, 24 episodes
ML - turns into another person when he touches someone for too long
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48. The Girl Who Sees Smells
Chinese Drama - 2023, 24 episodes
ML - supernatural disease
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49. Meeting You
Chinese Drama - 2020, 28 episodes
ML - social anxiety
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50. Love Unexpected
Chinese Drama - 2021, 24 episodes
ML - can't feel emotions
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51. The Only You
Chinese Drama - 2021, 22 episodes
FL - supernatural heart condition
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52. Your Sensibility My Destiny
Chinese Drama - 2021, 24 episodes
ML - no taste/touch/smell sensory perception
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53. Ashes of Love
Chinese Drama - 2018, 63 episodes
FL - can't access her emotions
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54. Kill Me, Heal Me
Korean Drama - 2015, 20 episodes
ML - multiple personality disorder
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55. Marry Me
Chinese Drama - 2020, 35 episodes
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56. Protect the Boss
Korean Drama - 2011, 18 episodes
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57. My Girlfriend Is an Alien
Chinese Drama - 2019, 28 episodes
ML - forgets women when it rains (?) rain phobia
FL - needs the touch of men to be well -
58. My Love from the Star
Korean Drama - 2013, 21 episodes
ML - kiss allergy
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59. My Unicorn Girl
Chinese Drama - 2020, 24 episodes
ML - face blindness
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60. Hello Mr. Gu
Chinese Drama - 2021, 30 episodes
ML - OCD, fear of crowds
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61. Crush
Chinese Drama - 2021, 24 episodes
FL - fear of the dark
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62. You're Beautiful
Korean Drama - 2009, 16 episodes
ML - night blindness
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63. Sweet Games
Chinese Drama - 2023, 24 episodes
FL - fear of the dark
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64. Don't Mess With Ex-Girlfriend
Chinese Drama - 2022, 20 episodes
ML - fear of the dark
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65. Sweet First Love
Chinese Drama - 2020, 24 episodes
FL - scared of driving in a car (due to car accident trauma)